This talk introduces a novel method for real-time monitoring of enzymatic hydrogelation using Electrochemical Impedance Spectroscopy (EIS) with Interdigitated Electrodes (IDEs). By analyzing impedance changes during the horseradish peroxidase (HRP)-catalyzed cross-linking of carboxymethyl cellulose-tyramine (CMC-TA) conjugates, the approach enables sensitive and precise assessment of gelation dynamics and reactant concentration effects. Additionally, a unique EIS signal interpretation model based on a modified Michaelis-Menten equation allows extraction of kinetic parameters, offering a powerful tool for optimizing hydrogel properties for biomedical applications.

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Bio

Dr. Gözde Kabay earned her postgraduate degrees in the Biomedical Engineering Department at TOBB University of Economics and Technology (TOBB ETU) in Turkey. During her doctoral studies, she focused on research in biosensor technology, biomaterials, drug delivery, and the plasma processing of materials for biomedical applications. Throughout her postgraduate education, she worked as a research fellow at Inha University and the University of Wisconsin-Madison.

After completing her postdoctoral work at the University of Freiburg, where she researched microfluidic-enhanced wearable biosensors, Dr. Kabay became the head of the Biosensor Laboratory at the Institute of Functional Interfaces (IFG) at the Karlsruhe Institute of Technology (KIT). Since 2024, she has served as the Junior Research Group leader of her multidisciplinary team, which is primarily focused on utilizing robotics and artificial intelligence to autonomously produce synthetic receptors and other materials for various applications, including diagnostics and drug delivery.

Other links:

• www.ifg.kit.edu/7665.php
  
• www.kabayresearchgroup.com/